In tissue and fluid samples isolated from individuals with numerous chronic inflammatory illnesses, IL-1β, IL-18, and other members of the IL-1 superfamily are expressed at high levels [29].The present study showed that the level of serum IL-1β and IL-18 in untreated RA cases was higher compared with treated RA cases and healthy control groups. The gene discussed is IL1B; the disease is rheumatoid arthritis.