In our study, we focused on gene expression of NLRP1, NLRC4, Caspase-1, and ASC inflammasomes to determine whether these inflammasomes included in the pathogenesis of RA through detection of the expression level of them in RA patients and healthy controls as well as to clarify the effect of treatment on their expression through detection of their expression level in treated and untreated cases. This evidence concerns the gene CASP1 and rheumatoid arthritis.