In previous research, AngII was used in vascular smooth muscle cell to explored its function, including inflammation and proliferation, which are involved in the pathology of hypertension and atherosclerosis [31]. Furthermore, the dysfunction of leukocytes, endothelium, white adipocytes and fibroblasts poses a risk for the development of aortic aneurysms under AngII induction. Here, AGT is linked to Hypertension.