Longitudinal growth data in relation to age in the three mutant groups and in control subjects with healthy body weight from age 1–15 years are presented in Figure S2 and S2 and Tables S3A. The mean height was significantly greater (p < 0.05) in children with MC4R deficiency than in the other two study groups, whereas no significant differences in growth were found between children deficient for LEP or LEPR (Table S3A). This evidence concerns the gene LEPR and hyperinsulinemic hypoglycemia, familial, 4.