The link between PAI-1 and senescence is well established in several models of senescence [45–47] and PAI-1 is considered a key marker of cellular senescence that contributes to the progression of various age-related diseases in humans such as emphysema, arterial thrombosis, arteriosclerosis, and hypertension [48, 49]. The gene discussed is SERPINE1; the disease is arteriosclerosis.