CXCL1 and neoplasm: Elegant studies have observed that KDM6A instructs the tumor microenvironment (TME) of PDAC, whereby Kdm6a-deficient murine PDAC cells exhibit increased levels of the CXC motif chemokine ligand 1 (CXCL1) with subsequent recruitment of neutrophils, thus highlighting the CXCL1-CXCR2 axis as a potential therapeutic target [82].