LRP5 and Camurati-Engelmann disease: Importantly, the identification of these mutations has facilitated the differential diagnosis of LRP5 HBM with other disorders such as osteopetrosis, progressive diaphyseal dysplasia (Camurati-Engelmann disease), Paget’s disease of the bone, and pycnodysostosis, all of which are often characterized by localized lesions [26].