Likewise, previous evidence revealed that TREM2 exerted robustly neuroprotective roles by anti-inflammation in several types of pathophysiological events, such as ischemic stroke, intracerebral hemorrhage and neurodegenerative diseases (Zhai et al. 2017; Chen et al. 2020; Jay et al. 2017). Here, TREM2 is linked to intracerebral hemorrhage.