STAT3 and polycystic ovary syndrome: In addition, SPX negatively influenced GC function by inhibiting cell proliferation via GALR2/3 and MAP3/1, STAT3, and AKT, and E2 secretion via GALR2/3 MAP3/1, and PKA, which is a feature of PCOS connected with inhibited ovulation and changes in hormones homeostasis.