SPX and polycystic ovary syndrome: In primary human GC, we observed that SPX at a dose of 100 nM decreased P4 secretion by GC of normal weight women, at doses 10 and 100 nM in obese women, at dose 100 nM in normal weight women with PCOS, and at 10 and 100 nM in obese women with PCOS (Figure 3E, P < 0.05).