Taken together, our data suggest that SUCLG2‐AS1 serves as an oncogene in NPC and, is correlated with lymph node metastasis and poor prognosis. SUCLG2‐AS1 recruits CTCF, which could mediate the interaction of SE of SOX2 with the promoter region, remotely enhancing the transcriptional activation of SOX2 and, promoting the invasion, metastasis and radioresistance of NPC. The gene discussed is CTCF; the disease is nasopharyngeal carcinoma.