Whole exome sequencing, somatic copy number alterations profiling, microarray analyses, collectively, revealed additional candidates, DEK, CRB1, MIR181, NUP205, IL8, IL6, MYC and SMAD3 [70–73], overexpressed in retinoblastoma and usually associated with aggressive retinoblastomas[69]. The gene discussed is SMAD3; the disease is retinoblastoma.