Through NGS methods, several lncRNAs have been identified as differentially expressed in RB and as potent regulators of RB progression and metastasis, including BANCR, AFAP1-AS1, NEAT1, XIST, ANRIL, PlncRNA-1, HOTAIR, PANDAR, DANCR and THOR. This evidence concerns the gene AFAP1 and retinoblastoma.