NOTCH1 and breast cancer: Upregulation of FBXW7 has been found to feature prominently in promoting chemosensitization in breast cancer due to its part in the control of ubiquitination and proteasomal degradation of resistance-associated targets in tumors, such as Notch1-IC, myeloid cell leukemia-1 (MCL-1), and heat shock factor 1 (HSF-1).