CCNE1 and breast carcinoma: More importantly, by analyzing FBXW7 mRNA levels in 23 patients with recurrent breast cancer, the time from recurrence to death is significantly shorter in the FBXW7-Low group than in the FBXW7-High group, and the Ki67 labeling index (50.6%) and cyclin E staining positivity (24%) are significantly higher than in the FBXW7-High group (30.7%, 8.3%) [74].