For instance, cophosphorylation of Serum/glucocorticoid-regulated kinase 3 (SGK3) with GSK-3β enhances the binding of FBXW7 to metastasis suppressor N-Myc downstream regulated gene 1 (NDRG1) and promotes NDRG1's ubiquitination, increasing breast cancer invasion and metastasis [97]. Here, FBXW7 is linked to breast carcinoma.