Significant challenges of FBXW7-targeted breast cancer therapeutic strategies include: how miRNA mimics or anti-miRNAs are transmitted is unknown; demethylation to restore FBXW7 expression may harm normally expressed genes; drugs cannot be targeted precisely due to the functional heterogeneity of FBXW7 isoforms; and the dual role of FBXW7 in breast cancer chemoresistance limits the action of chemotherapeutic agents. This evidence concerns the gene FBXW7 and breast cancer.