Similarly, modification of FBXW7-HIF-1α crosstalk by oncoproteins can disrupt FBXW7 to inhibit breast cancer angiogenesis, for example, TAR (HIV-1) RNA binding protein 2 (TARBP2) reduces the ubiquitination level and proteasomal degradation of HIF-1α by downregulating FBXW7-E3 ligase, which induces the formation of a hypoxic microenvironment and angiogenesis in breast cancer [108]. The gene discussed is FBXW7; the disease is breast cancer.