NCOA3 and cancer: Amplified in breast cancer 1 (AIB1) is abundant in high-grade invasive ductal carcinoma, research has suggested that FBXW7α can bind to the C2 domain of PTEN and promote the ubiquitination of AIB1 bound to the PTEN phosphatase domain, reducing AIB1 transcriptional activity and inhibiting MCF-7 cell proliferation [89, 99].