FBXW7 indirectly regulates breast cancer angiogenesis through its interaction with HIF-1α, and high HIF-1α expression is frequently observed in FBXW7-deficient breast cancers along with angiogenesis and migration, suggesting that normal FBXW7-HIF-1α binding is essential for remodeling normal vascular structure and tumor microenvironment (TME) [107]. The gene discussed is HIF1A; the disease is breast carcinoma.