Parallel to this, EZH2 inhibits FBXW7 and NUMB production by trimethylating histone H3 at Lys27 (H3K27me3), which activates anti-apoptotic genes and expresses T-cell multifunctional cytokines that attenuate immunosuppression in late tumor stages. The gene discussed is FBXW7; the disease is neoplasm.