TNF and breast cancer: found that silencing miR-182-5p in BT-549 and MDA-MB-231 cells significantly downregulates the expression of factors like p-p65, p-I-κB, tumor necrosis factor alpha (TNF-α), and IL-1β, while inhibiting FBXW7 restores NF-κB pathway-related complexes and promotes breast cancer apoptosis, proliferation, and decreased immune resistance [32] (Fig. 4).