ESR1 and breast carcinoma: Furthermore, in 1900 breast cancer cases from publicly available datasets, FBXW7 mRNA levels do not segregate with ER status, with ER- patients exhibiting lower FBXW7 expression, disease-free survival (DFS) and overall survival (OS), and that in basal-like subtypes group with higher FBXW7 expression has higher DFS [76].