Interestingly, while NF-κB interacts with and amplifies C/EBPδ in cancer cells, FBXW7, which is controlled by C/EBPδ, in turn triggers ubiquitination and destruction of NF-κB via GSK-3 phosphorylation, inhibiting the NF-κB cascade response in breast cancer [59]. The gene discussed is NFKB1; the disease is breast cancer.