Six proteins: carboxypeptidase N catalytic chain, glutathione peroxidase 3, apolipoprotein A-I, apolipoprotein C-I, complement C1q subcomponent subunit B and complement C1q subcomponent subunit C, showed a significant interaction with mood disorders or bone health-related variables for predicting overall cognitive function (Table 4 and Fig. 3). This evidence concerns the gene APOA1 and mood disorder.