The result revealed that target genes related to up-methylated circRNAs were mainly enriched in ten pathways, such as Valine, Leucine and isoleucine degradation, Tryptophan metabolism, Retinol metabolism, MAPK signaling pathway, Linoleic acid metabolism, GnRH signaling pathway, Fatty acid elongation, Fanconi anemia pathway, Carbon metabolism and Calcium signaling pathway (Fig. 6a). The gene discussed is GNRH1; the disease is Fanconi anemia.