APC and colorectal carcinoma: A total of 70–85% of CRC show widespread CIN [2] starting from APC gene inactivation leading to aberrant crypt formation (ACF) and progressing to adenoma and cancer via collective acquirement of activating mutations in oncogenes (KRAS, PIK3CA) and inactivation of tumor suppressor genes (SMAD4 and TP53) [3].