AKT1 and Proteus syndrome: The other disease-causing genes includes AKT1 for Proteus syndrome [18], MAP3K3 for verrucous venous malformation (VVM) [19], GNA11 for DCMO [20], RASA1 and EPHB4 with germline or somatic mutations for capillary malformation-arteriovenous malformation (CM-AVM) [21, 22], and so on.