After adjusting for sex, age, BMI, WC, SBP, and TGs, the linear association between FGF-21 and diabetes was also confirmed using multivariate logistic regression analysis (P for FGF-21 = 0.001; P for nonlinear = 0.091), suggesting that a curvilinear association between FGF-21 and the risk of newly diagnosed type-2 diabetes did not exist (Fig. 2B). This evidence concerns the gene FGF21 and type 2 diabetes mellitus.