CD274 and neoplasm: Recent research has revealed that PD-L1 is highly glycosylated on the membrane of tumor cells, and N-glycosylation of PD-L1, with a molecular weight of about 45 kDa on immunoblotting, which is crucial for PD-L1 protein stabilization by blocking PD-L1 from ubiquitin/proteasome-mediated destruction [24].