As GZMB targets caspase-3 upon entry into tumor cells and cleaved caspases to induce apoptosis [35], we compared the levels of cleaved caspase-3 (CCA3), where only a small number of cells underwent apoptosis in tumor tissues of CTRL mice, and strong aggregated apoptotic signals were widely observed in the sgFat4 mice (Fig. 3J and K). This evidence concerns the gene GZMB and neoplasm.