PTGS2 and colon adenocarcinoma: Fukata and colleagues [10] reported that LPS induces TLR4/COX-2 expression in the human colonic adenocarcinoma epithelial cell lines SW480 and T84 and in the mouse lamina propria macrophages RAW264.7, which results in the upregulation of the mucosal PGE2 detected in the tissue culture supernatants and mouse tissue samples.