ALK and non-small cell lung carcinoma: In 2007, Manabu Soda et al. first identified the fusion gene formed by Echinoderm Microtubule-associated protein-Like 4 gene (EML4) and Anaplastic Lymphoma Kinase (ALK) in NSCLC cells in the short arm of chromosome 2, which is another oncogenic driver gene different from the mutation of Epidermal Growth Factor Receptor (EGFR) [2].