For instance, the inhibition of the glucosylceramide synthase suppresses cisplatin-induced cholangiocarcinoma apoptosis via the inhibition of the ERK signaling pathway [25] while downregulation of B4GalT5 partially inhibits M1 macrophage-mediated adipose tissue inflammation by suppressing ERK signaling [46]. The gene discussed is B4GALT5; the disease is cholangiocarcinoma.