Moreover, the expression values of the GABAARα1, GABAARβ3, GABAARγ2, GABABR2, GAD65, NR2B, GluR1, LGI1, SCN1α, and EAAT2 were significantly lower, and the expressions of SCN1β and GFAP were significantly higher in the amygdala of epileptic patients with psychiatric disorders compared to those without psychiatric disorders (P ≤ 0.05; Fig. 4A-D). This evidence concerns the gene GRIN2B and psychiatric disorder.