Additionally, in the amygdala of epileptic patients with a duration of epilepsy exceeding 23 years, there was a significant increase in the expression of GABACRρ2 and a decrease in the expression of SCN2α compared to patients with a duration of epilepsy less than 23 years (P ≤ 0.05; Fig. 8A,C). This evidence concerns the gene SCN2A and epilepsy.