However, in melanoma, there was no correlation between the mRNA expression of GREB1 and ESR1 or AXIN2, but a strong positive correlation of mRNA expression of GREB1 with that of MITF or MLANA, one of MITF target genes [26, 27] in TCGA melanoma and cell lines data (Fig. 2A and Supplementary Fig. S2B). The gene discussed is ESR1; the disease is melanoma.