Tyr-CreER; BRAFV600E; PTENflox melanoma mice were crossed with the Is4+/− mice, generating control (Tyr-CreER; BRAFV600E; PTENflox; Is4−/−) and GREB1 Is4 (Tyr-CreER; BRAFV600E; PTENflox; Is4+/−) mice (Fig. 5E). This evidence concerns the gene GREB1 and melanoma.