A previous study demonstrated that resveratrol may be a potential therapeutic agent for diabetic cardiomyopathy through the autophagy signaling pathway37; therefore, we administered resveratrol to CREG1-knockdown NMCMs and examined the expression of autophagy-related proteins and the index of cardiomyocyte hypertrophy. This evidence concerns the gene CREG1 and diabetic cardiomyopathy.