MFN1 and breast cancer: To this end, miR-142 deficit was associated with MFN1 upregulation and mitochondrial fusion in mouse miR-142−/−BCR-ABL LSKs and human BC CML CD34+CD38− cells compared respectively with miR-142+/+BCR-ABL LSKs and CP CML CD34+CD38− cells (Fig. 5f, g; Supplementary Fig. 9g, h).