Using immunolabeled electron microscopy (EM) imaging, we showed that CpG-M-miR-142 also reduced the mitochondria-anchored MFN1 in both mouse miR-142−/−BCR-ABL LSKs and human BC CML CD34+CD38− cells (Fig. 5j, k; Supplementary Fig. 9m). The gene discussed is MFN1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.