Accordingly, we observed higher levels of PKCα and in turn of NRF2 (Supplementary Fig. 7a), PKCα/NRF2 interaction (Supplementary Fig. 7b) and p-NRF2 (Supplementary Fig. 7a), reduced NRF2 ubiquitination (Supplementary Fig. 7c), and increased both nuclear and cytoplasmic NRF2 (Supplementary Fig. 7d, e, left) in miR-142−/−BCR-ABL LSKs and human BC CD34+CD38− cells compared with their respective mouse and human controls. This evidence concerns the gene PRKCA and breast cancer.