Using elements of state transition and MI theories, we showed that the metabolism gene sets that were upregulated in miR-142−/−BCR-ABL LSKs compared with miR-142+/+BCR-ABL LSKs contained higher per-gene information than the remaining transcriptome to distinguish BC from CP LSKs, supporting the biological relevance of these genes to BC transformation. The gene discussed is ABL1; the disease is breast cancer.