To this end, we observed higher Msi2 mRNA and protein levels in LSKs from miR-142−/−BCR-ABL (BC CML) mice compared with those from miR-142+/+BCR-ABL (CP CML) mice (Supplementary Fig. 3a, b). Here, BCR is linked to chronic myelogenous leukemia, BCR-ABL1 positive.