MAP2 and inflammatory bowel disease: To test if the taxonomic profiles (both the abundance and coverage profile) by MAP2B can better distinguish IBD from non-IBD, we compared the PCoA plots and PERMANOVA pseudo-F statistic based on taxonomic profiles generated by different metagenomic profilers for the discovery cohort (n = 155) and validation cohort (n = 65) separately (Fig. 5a, “Methods”).