The downregulation of EGFR dramatically impaired IGF2BP3-induced cell proliferation, colony formation, and tumorigenesis, whereas the overexpression of EGFR partially restored the proliferation, colony formation, and tumorigenesis ability of IGF2BP3-knockdown cells (Fig. 4a–g and S4a–d), which supported EGFR as a critical target gene of IGF2BP3 in CRC. The gene discussed is EGFR; the disease is colorectal carcinoma.