Research by Venere et al. [23] showed that interference of KIF11 in malignant gliomas by a small molecule blocker can inhibit the proliferation of glial tumor stem cells and normal glial tumor cells, while the upregulation of KIF11 in glial tumor stem cells can inhibit the expression of cdh1, promote cell cycle G1 / S transformation, accelerate the cancer stem cell proliferation rate. The gene discussed is KIF11; the disease is malignant glioma.