RAC2 and autoimmune disease: Indeed, recent evidence derived from clinical and experimental animal models of autoimmune diseases has shown that statins exert immunomodulatory and anti-inflammatory effects beyond their lipid-lowering properties that may be beneficial in autoimmune diseases such as MS.2,3 Many of these effects are predominantly ascribed to statins' capacity to inhibit the isoprenylation (also known as prenylation or lipidation) of Rho small guanosine triphosphatases (GTPases, also known as small G-proteins).4, -, 6