PTX3 and Sepsis: It has been shown that statins, through inhibition of isoprenylation of Rac2, reduce oxidative stress during sepsis and downregulate pentraxin 3 in vascular cells during immune-inflammatory responses.36, -, 38 Furthermore, statins have been shown to induce the expression of several genes, including RAC2, that are involved in epidermal growth factor signaling39; however, the mechanism by which statins can induce RAC2 expression remains to be identified.