The mAb CERC-002 (NCT04412057) inhibits lymphotoxin-like, inducible protein (LIGHT), a cytokine within the tumour necrosis factor (TNF) family, which induces the release of other inflammatory cytokines, including granulocyte-macrophage colony-stimulating factor.38 40 This CT reported a statistically significant increase in the number of subjects alive and free of respiratory failure at day 28 of CERC-002 treatment (83.9% vs 64.5%; p=0.0440).38 This evidence concerns the gene CSF2 and respiratory failure.