By activating plasmin, these agents degrade fibrin, which accumulates and deposits in the pulmonary vasculature in a similar way in both CARDS and ARDS, leading to fibrosis and clot formation.31 59 Alteplase administration significantly improved PaO2/FiO2 ratios in CARDS patients by dissolving thrombi to increase blood flow (NCT04357730), also inferring potential efficacy in ARDS.54 The gene discussed is PLG; the disease is acute respiratory distress syndrome.