The proportion of circulating CD4+CD25+CD127lo/- Tregs was significantly decreased in LC patients as compared to HCs (p = 0.014; Fig. 1a and b, Fig. S1a) despite comparable numbers of CD3+CD4+ cells (p = 0.88; Fig. S1b). The gene discussed is CD4; the disease is laryngotracheoesophageal cleft.