Whereas Nrf2 expression level was comparable in LC and HC Tregs (p = 0.59; Fig. 3a), Nrf2 nuclear translocation in response to Prostaglandin J2 (PGJ2) stimulation was significantly impaired in LC patients (HC p = 0.0009; LC p > 0.99; Fig. 3b). Here, NFE2L2 is linked to laryngotracheoesophageal cleft.