VEGFA and Gastrointestinal obstruction: Although the pathogenesis remains unclear and there is no specific guideline for the management of anti-VEGF-induced GI perforation, the following options may help to reduce the mortality of patients with GI perforation.[7] Identification of individuals at high risk of GI perforation with a history of GI ulcer, diverticulosis, endoscopic evaluation, GI obstruction, and previous surgery is a crucial initial step in minimizing the incidence of GI perforation.