PROS1 and COVID-19: Induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), coronavirus disease 2019 (COVID-19) has become a great threat to public health.[1] Since the end of 2019, there have been more than 62 million confirmed cases of COVID-19 and more than 6.58 million deaths in a total of 213 countries as of December 2022, which has exerted an enormous impact on the medical industry and whole society.[2] SARS-CoV-2 is constructed by nucleocapsid (N protein), envelope (E protein), membrane (M protein), and spike (S protein).