Through relative mRNA expression analysis via TIMER2 and GEPIA databases, our findings point that down-regulated expression of NUMB exhibits in 14 of 33 total cancers, consisting of BLCA, BRCA, COAD, DLBC, LUAD, LUSC, OV, PRAD, READ, skin cutaneous melanoma, THCA, THYM, UCEC, and UCS. Here, NUMB is linked to cutaneous melanoma.