Furthermore, significant up-regulation of NUMBL was also found in CHOL, ESCA, HNSC, kidney renal clear cell carcinoma (KIRC), kidney renal papillary cell carcinoma (KIRP), LIHC, LUAD, LUSC, THYM, PAAD, and pheochromocytoma and paraganglioma (Fig. 1B and D). Here, NUMBL is linked to hereditary pheochromocytoma-paraganglioma.