NUMB and cutaneous melanoma: As shown in Figure 1A, the relative mRNA expression level of NUMB was significantly declined relative to the corresponding normal controls in bladder urothelial carcinoma (BLCA), breast invasive carcinoma (BRCA), colon adenocarcinoma (COAD), lung adenocarcinoma (LUAD), lung squamous cell carcinoma (LUSC), prostate adenocarcinoma (PRAD), rectum adenocarcinoma (READ), skin cutaneous melanoma, thyroid carcinoma (THCA), and uterine corpus endometrial carcinoma (UCEC).