Furthermore, significant up-regulation of NUMBL was also found in CHOL, ESCA, HNSC, kidney renal clear cell carcinoma (KIRC), kidney renal papillary cell carcinoma (KIRP), LIHC, LUAD, LUSC, THYM, PAAD, and pheochromocytoma and paraganglioma (Fig. 1B and D). The gene discussed is NUMBL; the disease is paraganglioma.