This study was prompted by a pancreatic ductal adenocarcinoma (PDAC) case analyzed within the Molecularly Aided Stratification for Tumor Eradication Research (MASTER) program of the National Center for Tumor Diseases (NCT) and the German Cancer Consortium (DKTK) (38) in which a BRAF exon 12 p.L485-P490delinsFS (BRAFdelinsFS) was detected. Here, BRAF is linked to pancreatic ductal adenocarcinoma.