IFNB1 and Zika virus infectious disease: To explore the function of LGP2 in regulating innate immune response during ZIKV infection, the mRNA level of IFNβ, interferon stimulated genes (ISGs) ISG56/myxovirus resistance protein 1 (Mx1), NFκB inhibitor α (IκBα), and proinflammatory cytokines interleukin 6 (IL6)/C-X-C motif chemokine 10 (CXCL10) was quantified by RT-qPCR in the LGP2-knockdown CCF-STTG1 cells during ZIKV infection (S2 Fig) [29,38].