The results indicate that LGP2 knockdown (siRNA si-2 shows the best inhibition effect was chosen) significantly increases the mRNA levels of IFNβ, ISG56, Mx1 and IL6 at multiple post infection time points (S2A and S2C–S2E Fig), and IκBα and CXCL10 at 24 hpi (S2B and S2F Fig). The gene discussed is DHX58; the disease is infection.