We previously reported the association among serum biomarkers of systemic inflammation (interleukins (IL) 1, -6, -8, -10, tumor necrosis factor [TNF]–α, C-Reactive Protein), neuroprotection (IGF-1), and astrocyte and glial activation (S-100β) measured at ICU admission and delirium duration, severity, and in-hospital mortality(3). Here, TNF is linked to delirium.