In colon and ileum, Turicibacter was positively correlated with tight junction protein ZO-1 and occludin expression but negatively correlated with serum cTnI and CK levels, the myocardial infarct area, HE score, apoptosis rate, inflammatory factors (IL-1β, IL-6, and TNF-α) in colon and ileum and serum LPS and Zonulin concentration (Fig 8). The gene discussed is IL6; the disease is hereditary elliptocytosis.