Pathophysiologically, glucose oscillation has been associated with increased oxidative stress, endothelial dysfunction, and inflammatory response, three key factors that have been involved in the development of cognitive dysfunction through a variety of downstream mechanisms, including detrimental connectivity of the brain network secondary to the dysfunction of Tau phosphorylation, plaque formation, synaptic transmission modulation, and dystrophic neurite growth [63–65]. This evidence concerns the gene MAPT and endothelial dysfunction.