MSH2 and breast cancer: Other studies in Saudi Arabian breast cancer patients showed that rare pathogenic variants in MUTYH gene and other MMR genes such as MLH1, MSH2, MSH6 may potentially increase the risk of breast cancer [76].https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10259259/ In addition, pathogenic variants in MUTYH gene and MMR genes were also reported in breast cancer patients from the UAE [77].