Using a panel containing 93 cancer predisposition genes in Egyptian patients with familial breast cancer, Nassar et al., [33] identified 27 deleterious germline variants in 11 cancer susceptibility genes including ATM, BRCA1, BRCA2, VHL, MSH6, APC, CHEK2, MSH2, MEN1, PALB2, and MUTYH. This evidence concerns the gene MSH2 and cancer.