As to LC and normal group, the 20 top proteins with the highest BC were APP, ACTB, NCAM1, APOB, PRNP, CDH2, SPP1, CRP, FGA, PIGR, CTSD, HP, APLP1, ENO2, AGT, CNTN2, SOD1, TIMP1, ITIH3 and NRXN1 (Supplementary Fig. 6). The gene discussed is ITIH3; the disease is breast cancer.