Yet, cardiac mRNA levels of atrial and B-type natriuretic peptide (Anp and Bnp), commonly used biomarkers for heart failure, and plasma levels of Troponin I, a marker of cardiomyocyte injury, were significantly increased in DOX- versus NaCl-treated WT, but not in Mpo−/− mice (Fig. 2f). This evidence concerns the gene NPPA and heart failure.