PLCG1 and infection: In summary, in this study, for the first time, we showed that BoHV-1 productive infection at later stages activates PLC-γ1 signaling, which promotes virions’ trafficking out of the Golgi apparatus, and the activated p-PLC-γ1(S1248) consistently associates with virions, representing a novel mechanism to regulate the virus replication deserving to be determined in the future.