As observed in MDBK cells, both PLC-γ1 and p-PLC-γ1(S1248) were readily detected in the isolated Golgi apparatus of A549 cells, and virus infection for 24 hours increased the protein levels of p-PLC-γ1(S1248) but decreased that of total PLC-γ1 (Fig. 3B), suggesting that virus productive infection in A549 cells also increased the activity of PLC-γ1. This evidence concerns the gene PLCG1 and viral infectious disease.