We implanted parental and SIN3A/3B-DKO MDA-MB-231 cells and FL SIN3A or SIN3A (Δ708–728) deletion mutant rescue cells, respectively, into the mammary fat pad of female NSG mice, and found that single expression of FL SIN3A partially reversed the inhibitory effect of SIN3A/3B DKO on tumor growth, angiogenesis, lymphangiogenesis, and distant metastasis to lungs and liver in mice (Figure 6, C–G). This evidence concerns the gene SIN3A and neoplasm.