To rule out the possibility that reduced metastatic burden in mice bearing SAP30-KO or -KD tumors is due to the reduced primary tumor volume, we euthanized SAP30-KO tumor–bearing mice 15 days later than control mice when SAP30-KO tumor volumes matched with those of SC tumors in mice at day 48 (Supplemental Figure 2N). This evidence concerns the gene SAP30 and neoplasm.