CD274 and lung cancer: Similarly, we found that the KP autochthonous model of lung cancer demonstrated a partial response to single-agent anti–PD-L1 as measured by lung CT scans taken after 4 weeks of treatment (Figure 1D); however, the model generated from anti–PD-L1–treated lung tumors (termed KPPDL1) demonstrated upfront resistance when rechallenged subcutaneously in vivo as compared with IgG-treated lung tumors (KPIgG) (Figure 1E).