ENPP2 and neoplasm: We also tested ATX inhibition with anti–PD-L1 in the KPIgG model and found that after 4 weeks of treatment, the combination treatment arm had significantly smaller tumors compared with the vehicle-treated tumors (Supplemental Figure 6E), whereas in the KPPDL1 resistant model, ATX inhibitor alone was sufficient to significantly repress tumor growth (Supplemental Figure 6F).