To understand how the observed expression in the experimental models relates to patient samples, we analyzed ENPP2 gene expression as a function of inflammatory gene signatures in 3 independent NSCLC data sets: the BATTLE-2 trial of metastatic NSCLC (29) and the Immunogenomic Profiling of Non–Small Cell Lung Cancer Project (ICON) (30) and The Cancer Genome Atlas (TCGA) data sets of early-stage surgically resected tumors (Figure 3, F–I). Here, ENPP2 is linked to small cell lung carcinoma.