CASP3 and neoplasm: To establish the inherent chemoresistance of these subsets, SCC VII-Luc/GFP tumors were grown in groups of mice for 10 days, and cell death was assessed by measuring active caspase-3 in tumor cells 7 days after either saline or a maximum tolerated dose of cisplatin was delivered i.p. CD44hi tCSC had lower overall active caspase-3 compared with CD44lo tumor cells in saline-treated mice.