Squamous cell carcinoma VII (SCC VII) is a spontaneously arising MHC II− murine tumor that closely resembles human head and neck squamous cell carcinoma (HNSCC) in several key features including pulmonary and lymph node (LN) metastasis, poor immunogenicity, and, importantly, resistance to chemotherapeutic and immunotherapeutic intervention (38–41). The gene discussed is HLA-C; the disease is head and neck squamous cell carcinoma.