Therefore, in addition to CD4+/CD8+ T cell NeoAg vaccination programming help at priming in the tumor-draining LN, it may also induce other CD4+ T cell responses at later time points, such as the arrival of CD4+ Tfh-like cells in the TME as we highlight in this work, to improve the quality of the CD8+ T cell response—as enhanced effector function and/or ability to resist exhaustion. The gene discussed is CD4; the disease is neoplasm.