This corroborates the immune exclusion phenotype shown in Figure 1F. In ICB-treated BrM, whose myeloid cell populations displayed a strong IFN response, most immune cells left the perivascular space and diffusely infiltrated the tumor tissue (Figure 5E); this migration explains the significant decrease of MRC1+ macrophages near the vascular regions seen in both the ST and mIF data (Figure 5, D and F, and Supplemental Table 4D). The gene discussed is IFNA1; the disease is neoplasm.