CD4 and neoplasm: The clustering of tumor-infiltrating lymphoid (TIL) cells (n = 22,092 cells in BrM; n = 10,416 in rGBM) identified 3 CD4+ clusters, 8 CD8+ enriched clusters, a double-negative memory-like cluster (CD4–CD8–-Tm), a proliferating population (cycling), and 2 NK cell clusters (Figure 2, A and B).