KDM6A and diabetes mellitus: This same epigenetic mark can be erased by lysine-specific demethylase 6 (KDM6)A and KDM6B (Agger et al., 2007; Lan et al., 2007; Lee et al., 2007), and we previously reported that inhibition of KDM6 demethylases attenuated glomerular disease caused by diabetes, adriamycin nephrotoxicity or renal mass ablation (Majumder et al., 2018), a finding substantiated elsewhere (Lin et al., 2019).