Akkermansia muciniphila enrichment was observed in Nlrp6 and Il10 double-deficient mice and can induce intestinal inflammation in germ-free and specific-pathogen-free Il10-deficient mice.42 Additionally, 1,25(OH)2D3 deficiency has been linked to increased Akkermansia muciniphila and colon inflammation phenotypes in Cyp27b1 knockout mice.43 These seemingly contradictory effects may be attributed to specific strain differences, necessitating further studies to elucidate their roles in IBD. This evidence concerns the gene CYP27B1 and inflammatory bowel disease.