For instance, Do et al. demonstrated the increased infiltration of B lymphocytes within the inflamed LP in DSS colitis47 and posited that the HDAC6 inhibitor BML-281 selectively attenuated B cell infiltration into the LP, potentially contributing to the amelioration of colonic inflammation.47 Conversely, Wang et al. found that DSS-treated mice exhibited more severe colitis in the absence of B cells, while the adoptive transfer of B cells attenuated the disease.49 IgA-producing plasma cells are essential to maintaining intestinal homeostasis in the normal gut. The gene discussed is HDAC6; the disease is colitis.