Brain amino acid overutilization in FTD may follow increased synthesis of protein aggregates (Raz et al., 2016), including cellular p-tau (Lee et al., 2001) and FTD-transactive response DNA-binding protein-43 (TDP-43) (Davidson et al., 2007; Hu and Grossman, 2009). Here, TARDBP is linked to frontotemporal dementia.