Hyperinsulinemia increases the phosphorylation of tau proteins (Clodfelder-Miller et al., 2006; Planel et al., 2007), the formation of senile plaques (De la Monte and Wands, 2005), and inhibits the degradation of extraneuronal Aβ (Qiu et al., 1998). The gene discussed is MAPT; the disease is Hyperinsulinemia.