Such R175H-specific TCRs were isolated from TILs and peripheral blood lymphocytes of several patients and recognize target cells transfected with a p53 R175H minigene as well as tumor lines naturally expressing the p53 mutation (Kim et al. 2022; Lo et al. 2019; Malekzadeh et al. 2019, 2020). Here, TP53 is linked to neoplasm.